Honey is derived from nectar gathered and modified by the honeybee, Apis mellifera. It’s a carbohydrate-rich syrup derived from floral and different vegetation nectars and secretions. Honey has been utilized in folks medication since historical instances and has extra lately been rediscovered by medical researchers for its use in dressing acute and power wounds. Historically, honey has been used to deal with burns, contaminated and non-healing wounds and ulcers, boils, pilonidal sinus, venous and diabetic foot ulcers (1-6). Current research affirm the efficacy of honey in treating venous ulcers (7). In sufferers affected by malignant wounds, enchancment with respect to wound dimension and cleanliness was seen after remedy with honey-coated bandages (8). Equally, honey dressing quickened charges of therapeutic in stress wounds. Honey has additionally been used to reduce foul odors emanating from wounds which trigger a social barrier for sufferers and should result in isolation. There are additionally experiences of utilizing medihoney to scale back the signs of power ocular floor ailments (9, 10). Unrefined honey has anti-inflammatory, anti-bacterial and anti-oxidant properties (11). The antibacterial motion is because of its acidity, hydrogen peroxide content material, osmotic results, dietary and antioxidant content material, stimulation of immunity, and unidentified compounds (12). Completely different sorts of honey like Gelam, Medihoney, Tualang and Manuka, have been examined and located to have comparable properties. Some types of medically-certified honeys have been licensed as medical merchandise for skilled wound care in Europe and Australia (4, 10, 13). Medihoney reveals a typical antibacterial exercise, which has been confirmed by many in vitro testing research. Medihoney is sterilized by gamma irradiation (10). As Clostridium botulinum spores exist in the environment (soil, air, mud and in agricultural merchandise), it’s crucial to inactivate the spores. If a deep wound is contaminated by micro organism in an anaerobic surroundings, there’s the likelihood that the proliferation of spores and manufacturing of botulinum toxin will happen. Botulinum toxin can have systemic results equivalent to paralysis and cardiac arrhythmia (10). Honey has been heated to eradicate the spores, and this takes place underneath 120 levels centigrade temperature for 10 minutes. Nonetheless, this could alter a few of honeys’ useful properties. Glucose oxidase just isn’t warmth resistance. Subsequently, gamma irradiation was launched to destroy sometimes seen spores in honey, whereas having no opposed impacts on honey’s useful properties (10). Medihoney just isn’t thought of to be an antiseptic agent as a result of it doesn’t meet all standards of a wound antiseptic. The next are 4 of them:
1) Fast impact on completely different sorts of micro organism and completely different fungi;
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2) Acceleration of the physiological means of wound therapeutic (debridement and granulation);
3) No native or systemic opposed results (allergy or toxicity);
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4) Price effectiveness.
Honey meets all however the first criterion (10). physique of proof from printed literature exists, recommending the routine scientific use of honey. Honey is the oldest wound dressing materials identified to human, when some trendy merchandise are failing on this space. Laboratory research present additional proof supporting its use in wound dressing as a result of its bioactivities. Honey stimulates leukocytes to launch cytokines, which is what initiates the tissue restore course of. It additionally stimulates immune response to an infection. The stimulation of different points of the immune system by honey can be evident (Proliferation of B- and T- lymphocytes and the motion of phagocytes). Honey stimulates the manufacturing of antibodies. It’s advised that this, is because of honey impact of enhancement of the immune system and antibacterial exercise. The antibacterial exercise of honey is in a broad spectrum as evidenced by many research. The aim of this assessment is to establish up-to-date proof to be able to convey extra armamentarium to a practitioners desk for treating related situations.
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